Normal Human Kidney Proximal Tubule Cells

人腎近端小管細(xì)胞

Normal Human Kidney Proximal Tubule Cells- (NhKPT)  are obtained from the cortical part of the human kidney and are an integral part of the nephron. The proximal tubule regulates the pH of the filtrate by exchanging hydrogen ions for bicarbonate ions in the filtrate; it is also responsible for secreting organic acids, such as creatinine and other bases, into the filtrate.

NhKPT cells are isolated from the kidney cortex after removal of the kidney capsule and medulla. After digestion of the cortex, a pure population of NhKPTs are isolated by positive magnetic selection.

Proximal tubule cells are characterized by yield, viability, and morphology. The purity is analyzed by immunostaining for proximal tubule specific markers aquaporin 1, ENT1, Na+K+ATPase and, cytokeratin. NhKPT cells are terminally differentiated and can be expanded for at least 15 population doublings. Proximal tubules are further evaluated for γ-glutamyl transferase activity and tight junction formation by staining with ZO1.

THESE PRODUCTS ARE FOR RESEARCH USE ONLY and NOT approved for use in humans or clinical diagnostic testing.

Normal Human Kidney Proximal Tubule Cells

人腎近端小管細(xì)胞

PBMC分離試劑盒

人外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

人PBMC分離試劑盒 人PBMC分離液

猴外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

猴PBMC分離試劑盒 猴PBMC分離液

比格犬外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

比格犬PBMC分離試劑盒 比格犬PBMC分離液

狗外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

狗PBMC分離試劑盒 狗PBMC分離液

大鼠外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

大鼠PBMC分離試劑盒 大鼠PBMC分離液

小鼠外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

小鼠PBMC分離試劑盒 小鼠PBMC分離液

兔外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

兔PBMC分離試劑盒 兔PBMC分離液

豬外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

豬PBMC分離試劑盒 豬PBMC分離液

豚鼠外周血單個(gè)核細(xì)胞分離試劑盒PBMC分離液

豚鼠PBMC分離試劑盒 豚鼠PBMC分離液

骨髓單個(gè)核細(xì)胞分離試劑盒Bone Marrow Mononuclear Cells Isolation Kit

脾單個(gè)核細(xì)胞分離試劑盒 Spleen Mononuclear Cells Isolation Kit

紅細(xì)胞分離試劑盒

人紅細(xì)胞分離試劑盒 紅細(xì)胞分離液

猴紅細(xì)胞分離試劑盒 紅細(xì)胞分離液

比格犬紅細(xì)胞分離試劑盒 紅細(xì)胞分離液

大鼠紅細(xì)胞分離試劑盒 紅細(xì)胞分離液

小鼠紅細(xì)胞分離試劑盒 紅細(xì)胞分離液

ADME相關(guān)產(chǎn)品

Ⅰ相代謝穩(wěn)定性試劑盒

Ⅱ相代謝穩(wěn)定性試劑盒

CYP450 酶代謝表型研究試劑盒（化學(xué)抑制法/7種抑制劑）

CYP450 酶代謝表型研究試劑盒（重組酶法/7種酶）

CYP450 酶代謝表型研究試劑盒（重組酶法/單酶）

酶抑制（IC50）研究試劑盒（7種特異性底物）

酶抑制（IC50）研究試劑盒（單個(gè)酶）

NADPH再生系統(tǒng)

UGT孵育系統(tǒng)

0.1M PBS

肝微粒體（人，猴，犬，大鼠，小鼠）

肝S9（人，猴，犬，大鼠，小鼠）

肝原代細(xì)胞（人，猴，犬，大鼠，小鼠）

CYP450（CYP1A2，CYP2A6，CYP2B6，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1，CYP3A4）

UGT酶

探針底物，代謝產(chǎn)物，抑制劑（CYP1A2，CYP2A6，CYP2B6，CYP2C8，CYP2C9，CYP2C19，CYP2D6，CYP2E1，CYP3A4）

ADME服務(wù)項(xiàng)目

肝微粒體代謝穩(wěn)定性（人，猴，犬，大鼠，小鼠）

肝細(xì)胞代謝穩(wěn)定性試驗(yàn)（人，猴，犬，大鼠，小鼠）

代謝表型研究

代謝產(chǎn)物鑒定

代謝途徑鑒定

種屬比較研究

CYPP450抑制實(shí)驗(yàn)（CYP1A2，CYP2A6，CYP2C9，CYP2C19，CYP2D6，CYP2E1，CYP3A4）

CYPP450誘導(dǎo)實(shí)驗(yàn)

血漿蛋白結(jié)合率測(cè)定

血漿穩(wěn)定性試驗(yàn)

跨膜轉(zhuǎn)運(yùn)試驗(yàn)

藥物-藥物相互作用

毒理學(xué)研究

Innovative Reagents for Innovative Research

匯智和源致力于為創(chuàng)新藥企業(yè)及生命科學(xué)研究機(jī)構(gòu)提供高品質(zhì)的生物試劑。